Alpha BRAIN® is a dietary supplement comprised of well researched earth-grown nutrients, amino acids, and vitamin B6. It has clinically demonstrated in two double blind and peer reviewed trials the ability to help significantly improve multiple areas of cognition. What makes it more unique was that the trials conducted by the Boston Center for Memory were successful on healthy subjects. This suggests that Alpha BRAIN may help improve mental performance for every healthy adult human in the universe.
ac-11® – Cat’s Claw Extract
The Amazon rainforest is the home of Cat’s Claw (Uncaria tomentosa), a plant revered by traditional cultures for its inherent properties. After years of research, the creators of ac-11® developed a hot water extraction process based on a proprietary molecular sieving technology, creating ac-11® – the Rainforest Super Herb. ac-11® is the perfect marriage of the rainforest’s secrets with today’s advancements in phytonutrient science.
Derived from lecithin, L-Alpha glycerylphosphorylcholine, also known as Alpha GPC, is a phospholipid derivative found concentrated in important brain cell membranes. Unlike less expensive forms of choline such as choline bitrartate, Alpha GPC has been shown to be well absorbed, easily crossing the blood-brain barrier. As source material for the neurotransmitter acetylcholine, Alpha GPC helps support cognitive function by improving the body’s ability to synthesize acetylcholine. Acetylcholine has been linked to memory, focus and REM sleep states.
Huperzia serrata is the second part of Alpha BRAIN’s two pronged strategy to help increase resources of the vital neurotransmitters. An extract from a plant in the clubmoss family (Huperzia serrata), Huperzine A is a naturally derived acetylcholinesterase inhibitor. Acetylcholinesterase (AchE) is responsible for the breakdown of acetylcholine. By effectively inhibiting AchE, more acetylcholine is made available. In independent study, efficacy has been shown in a range of 200-400 mcg daily, and safety has been demonstrated in trials up to 5 weeks and 600 mcg daily.
Bacopa monnieri is an Ayurvedic herb found in primarily in India, believed to help support cognitive health. Ayurvedic masters have touted its effects for centuries, as Bacopa has been served to Rajas and peasants alike. Bacosides, an active compound in Bacopa, are thought to play a key role in memory and general cognitive health.
Alpha BRAIN Research
The cognitive performance improvements of Onnit’s flagship nootropic were analyzed by two double blind, randomized, placebo controlled trials performed at the Boston Center for Memory.
In the flagship study over 60 subjects were assessed in multiple areas of cognitive function. By the end of the study, the subjects who were randomly assigned to take Alpha Brain for 45 days showed significant improvement (p<0.05) in the areas of executive function, verbal memory and processing speed.
This trial is one of the first studies of a multi-ingredient nootropic supplement to show improvement in these areas and provides a framework for further nootropic research.† The data has been accepted for presentation at the International Society of Sports Nutrition and future publication.
Though many of the individual compounds in Alpha BRAIN have shown cognitive benefits in prior studies, Onnit aimed to test the complete Alpha BRAIN formula in a population of healthy individuals with above average intelligence.
The ability to recall a long list of words was significantly greater in the subjects who comprised the Alpha BRAIN group. This finding replicated initial data from a pilot study that also showed memory enhancement, amounting to a total of 80 subjects who completed the cognitive testing.
A randomized subset of subjects from the clinical trial participated in having their brain waves and processing speed measured by electroencephalogram (EEG). Despite the smaller sample size, robust differences were found in the brain wave frequency detected when subjects relaxed and closed their eyes. Subjects who took Alpha BRAIN had a higher frequency peak Alpha Wave, a type of synchronous neural oscillation that reflects a state of calm focus and attention.
How fast does Alpha BRAIN work?
To answer this question, researchers looked at brain activity of subjects after a single dose of Alpha BRAIN. Subjects were asked to listen and respond to particular target tone and ignore distractor non-target tones. Those who took Alpha BRAIN, after a single dose, demonstrated shorter responses times and higher amplitude electrical activity when performing the task compared to the placebo-controls. In other words, there is evidence that Alpha BRAIN may work after the very first dose.
Furthermore, when performing EEG tests after 45 days of supplementation, the Alpha BRAIN group continued to outperform the placebo counterparts. There was a significant improvement in both peak Alpha brain function, a brain wave measure that is often associated with cognitive performance, and linked to the elusive flow state. These randomized, controlled clinical trials reflect Onnit’s dedication to evidence based approaches in health optimization.
Our studies not only affirm Alpha BRAIN’s effectiveness, but also demonstrates there are tools available to enhance cognitive performance in healthy individuals. We aim to further our research efforts and improve our understanding on how performance of the mind and body can be maximized.
Active Ingredients & Use
Alpha BRAIN Ingredients
L-Tyrosine: L-tyrosine is an amino acid precursor that helps the body with the production of the neurotransmitter L-dopa.
L-Theanine: L-theanine is credited as one of the major reasons why green tea is much smoother than any other caffeinated beverage. Closely related to the GABA mechanism and easily absorbed by the body, L-theanine helps to maintain balance in the Alpha BRAIN formula.
Oatstraw (Avena sativa): Oatstraw is a mildly relaxing herb that has a history of traditional use as one of nature’s stress-management nutrients.
Phosphatidylserine: Phosphatidylserine (PS) is an essential lipid compound abundant within brain cell membranes.
Pterostilbene: An antioxidant naturally abundant in blueberries, this particular compound helps the body with the reduction of oxidative stress.
Vitamin B6: One of the body’s busiest vitamins, involved in an numerous biological reactions in the body. One of its primary tasks is to aid in the synthesis of amino acids and neurotransmitters.
Alpha BRAIN Is Certified Drug Free
By The Banned Substances Control Group
The BSCG Certified Drug Free® program represents the gold standard in third party dietary supplement testing and certification. Overseen by renowned drug-testing pioneer Dr. Don Catlin and his son Oliver Catlin, BSCG’s rigorous science-first program ensures that supplement products and ingredients are free of drugs and other harmful agents that can lead to health concerns or positive drug tests. BSCG’s expert testing enables companies to establish their brands and products as safe, reputable and drug free and provides athletes and consumers with trusted supplement options.
Finished products are tested for more than 392 drugs, including 207 banned in sport and 185 prescription and over-the-counter drugs not banned in sport. BSCG tests for more banned substances in sport than any other supplement certification program and is the only program to include testing for prescription and over-the-counter drugs not banned in sport.
Other key elements of BSCG’s certification program include a manufacturing audit focusing on 21 C.F.R. 111 – Good Manufacturing Practices (GMP) compliance, a toxicology evaluation and review of raw material and label verification testing for each product, and annual random testing for ingredient or label verification and contaminants including heavy metals, pesticides, solvents and microbiological agents.
Alpha BRAIN Video Gallery
Pro Mma Athlete
“I definitely feel sharper and my awerness is much better every time I use my Alpha Brain caps. I’ve used it for long days at the office as well and not only for my sport and would recommend it to anyone that need to stay sharp and one step ahead”
- Former Invicta FC atomweight champion.
I enjoy the focus Alpha BRAIN brings to my training, I feel like I am more able to get in the zone when I take it.